Ketorolac in Postoperative Neonates and Infants: A Systematic Review
| Autor: | Sadie B. Stone |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
education.field_of_study
business.industry Population MEDLINE Review 030204 cardiovascular system & hematology body regions Ketorolac 03 medical and health sciences 0302 clinical medicine Search terms Pharmacokinetics 030202 anesthesiology Anesthesia Pediatrics Perinatology and Child Health medicine Morphine Pharmacology (medical) Dosing education business Adverse effect medicine.drug |
| Zdroj: | J Pediatr Pharmacol Ther |
| ISSN: | 1551-6776 |
| Popis: | OBJECTIVE To evaluate the pharmacokinetics and pharmacodynamics, dosing, efficacy, and safety of ketorolac in postoperative patients younger than 6 months of age. METHODS PubMed (1988–July 2020), Medline (1946–July 2020), and EBSCO Discovery Service (1988–July 2020) were searched to identify relevant published articles using the following search terms: ketorolac, neonate, infant. English-language articles evaluating the use of ketorolac in infants younger than 6 months of age were included. RESULTS Eight reports that included 239 infants receiving ketorolac were included. Of the included patients, 237 were younger than 6 months of age. Ketorolac exhibits rapid elimination of the analgesia-producing S (−) isomer, elimination half-life of 0.83 hours. Most patients received 0.5 mg/kg/dose every 6 hours for 48 to 72 hours. Analgesia was demonstrated by reduced use of open-label morphine and significant lowering of Neonatal/Infant Pain Scale scores. Adverse effects were minimal when ketorolac was used in term neonates and infants without baseline renal dysfunction. CONCLUSIONS Randomized placebo-controlled trials of ketorolac use in this population are lacking; however, most published reports noted efficacy and safety with ketorolac in properly selected infants. |
| Databáze: | OpenAIRE |
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