Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome

Autor: Huynh Giao Ly, Kei Takase, Shunji Mugikura, Tomohiko Muratsubaki, Lukas Van Oudenhove, Makoto Yoshizawa, Shin Fukudo, Joe Morishita, Motoyori Kanazawa, Mao Yagihashi, Michiko Kano, Patrick Dupont, Keiji Kohno, Yukari Tanaka
Rok vydání: 2017
Předmět:
Adult
Male
Hypothalamo-Hypophyseal System
endocrine system
medicine.medical_specialty
Colon
Corticotropin-Releasing Hormone
Brain activity and meditation
Pituitary-Adrenal System
lcsh:Medicine
Adrenocorticotropic hormone
Gyrus Cinguli
Article
Irritable Bowel Syndrome
03 medical and health sciences
Basal (phylogenetics)
Corticotropin-releasing hormone
0302 clinical medicine
Adrenocorticotropic Hormone
Stress
Physiological
Internal medicine
Humans
Medicine
lcsh:Science
Anterior cingulate cortex
Irritable bowel syndrome
Multidisciplinary
medicine.diagnostic_test
business.industry
lcsh:R
medicine.disease
Magnetic Resonance Imaging
Endocrinology
medicine.anatomical_structure
Female
lcsh:Q
030211 gastroenterology & hepatology
Gastrointestinal Motility
business
Functional magnetic resonance imaging
hormones
hormone substitutes
and hormone antagonists
030217 neurology & neurosurgery
Hormone
Zdroj: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-017-09635-x
Popis: Stress is a known trigger of irritable bowel syndrome (IBS) and exacerbates its gastrointestinal symptoms. However, underlying the physiological mechanism remains unknown. Here, we investigated hypothalamic–pituitary–adrenal (HPA) axis, colonic motility, and autonomic responses to corticotropin-releasing hormone (CRH) administration as well as brain activity alterations in IBS. The study included 28 IBS patients and 34 age and sex-matched healthy control subjects. IBS patients demonstrated greater adrenocorticotropic hormone (ACTH) responses to CRH than control subjects. Male IBS patients had greater increases in colonic motility than male HCs after CRH. Female IBS patients showed altered sympathovagal balance and lower basal parasympathetic tone relative to female control subjects. Brain responses to rectal distention were measured in the same subjects using functional magnetic resonance imaging, and their associations with individual ACTH responses to CRH were tested. A negative association between ACTH response to CRH and activity in the pregenual anterior cingulate cortex (pACC) during rectal distention was identified in controls but not in IBS patients. Impaired top-down inhibitory input from the pregenual ACC to the HPA axis may lead to altered neuroendocrine and gastrointestinal responses to CRH. Centrally acting treatments may dampen the stress induced physical symptoms in IBS.
Databáze: OpenAIRE
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