Hyperlipoproteinemia and cholesterol deposition at the arteries of I 131-treated dogs
| Autor: | Sherman S. Wilson, A. A. Renzi, Lawrence J. Milch, Lesly G. Robinson, Norman Weiner |
|---|---|
| Rok vydání: | 1958 |
| Předmět: |
Blood lipoprotein
Blood protein disorder medicine.medical_specialty Hyperlipoproteinemias Lipoproteins Blood lipids Biology General Biochemistry Genetics and Molecular Biology Iodine Radioisotopes chemistry.chemical_compound Blood serum Dogs Internal medicine medicine.artery medicine Animals Aorta Cholesterol Arteries Lipid Metabolism medicine.anatomical_structure Endocrinology chemistry lipids (amino acids peptides and proteins) Artery Lipoprotein Iodine |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 97(1) |
| ISSN: | 0037-9727 |
| Popis: | SummaryDogs maintained for a year after I131 administration were found to achieve average maintenance levels of serum cholesterol in excess of 430 mg % and comparably elevated concentrations of other serum lipid and lipoprotein parameters. Tissue analysis at autopsy revealed significantly elevated levels of coronary artery, aorta, and liver cholesterol in male treated dogs, as compared with control males. Treated female dogs differed from treated males in developing significantly higher levels of Sf 0–12 blood lipoproteins, and slightly, possibly significantly, lower levels of coronary artery cholesterol. No correlation between altered tissue cholesterol content and any of the serum lipid or lipoprotein moieties was observed. |
| Databáze: | OpenAIRE |
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