Characteristic and Early Discontinuation of Obsessive-Compulsive Disorder Trials Registered on ClinicalTrials.gov
| Autor: | Shanxia Luo, Qiong Guo, Liu Yang, Yifan Cheng, Youlin Long, Xinyi Wang, Liqin Liu, Zixin Yang, Tengyue Hu, Liang Du, Min Chen, Ga Liao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Drug trial Early discontinuation Behavioral therapy RC435-571 behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Obsessive compulsive Internal medicine Medicine 030212 general & internal medicine Original Research underreporting Psychiatry business.industry Proportional hazards model Hazard ratio early discontinuation Confidence interval delayed reporting Discontinuation obsessive-compulsive disorder Psychiatry and Mental health business 030217 neurology & neurosurgery clinicaltrials.gov |
| Zdroj: | Frontiers in Psychiatry Frontiers in Psychiatry, Vol 12 (2021) |
| ISSN: | 1664-0640 |
| Popis: | Objective: This study aimed to analyze the characteristics and reasons of early discontinuation of obsessive-compulsive disorder (OCD) trials registered on ClinicalTrials.gov.Methods: OCD trials and relevant publications were searched on ClinicalTrials.gov and PubMed, respectively. The characteristics and details regarding the timely publication of trials were recorded. Cox regression analysis was used to explore factors associated with the early discontinuation of OCD trials.Results: The analysis included 298 OCD therapy trials. Most investigations recruited 70% were published at least 1 year after completion. Behavioral therapy trials were the most common type of major treatment-aimed OCD trials (39%), followed by drug trials (35.1%) and device/procedure trials (24.7%). The univariate Cox regression analysis indicated that drug trials [hazard ratio (HR) = 2.56, 95% confidence interval (CI): 1.21–5.43], absence of collaborators (HR = 3.87, 95% CI: 1.62–9.26), and sponsorship by industry (HR = 3.97, 95% CI: 1.49–10.53) were risk factors for early discontinuation of OCD trials. Further multivariate Cox regression showed that drug trials (HR = 3.93, 95% CI: 1.71–9.08) and absence of collaborators (HR = 5.17, 95% CI: 1.97–13.54) were independent risk factors for early trial discontinuation of OCD trials. The sensitivity analysis confirmed these results. Non-drug trials (OR = 3.32, 95% CI: 1.21–9.11), absence of collaborators (OR = 3.25, 95% CI: 1.10–9.60), and non-blinded trials (OR = 5.23, 95% CI: 1.05–26.2) were independent risk factors for unreported results in registry.Conclusion: The diagnosis and prevention of OCD are rarely investigated in trials. Underreporting and delayed reporting remain major problems. The type of intervention and participation of collaborators are associated with early discontinuation of OCD trials. |
| Databáze: | OpenAIRE |
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