Level and determinants of serum perfluoroalkyl acids (PFAAs) in a population in Klang Valley, Malaysia
| Autor: | Mustafa Ali Mohd, Emmy Dayana Ahmad, Mohd Redzuan Ramli, Minoru Yoneda, Didi Erwandi Mohamad Haron |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Perfluorooctanesulfonic acid Population 010501 environmental sciences 01 natural sciences Perfluorononanoic acid 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Tandem Mass Spectrometry Negatively associated Environmental health Biomonitoring Humans Medicine 030212 general & internal medicine education 0105 earth and related environmental sciences Fluorocarbons education.field_of_study business.industry Dietary intake Fatty Acids Malaysia Public Health Environmental and Occupational Health Environmental Exposure Serum samples Alkanesulfonic Acids chemistry Environmental Pollutants Female business Decanoic Acids Body mass index Chromatography Liquid Environmental Monitoring |
| Zdroj: | International Journal of Hygiene and Environmental Health. 223:179-186 |
| ISSN: | 1438-4639 |
| DOI: | 10.1016/j.ijheh.2019.09.005 |
| Popis: | For decades, perfluoroalkyl acids (PFAAs) have been commonly used for industrial and commercial purposes due to their water- and stain-resistant properties. Persistent pollutants that contain PFAAs have been associated with adverse health effects in humans, and many studies have documented dietary intake, indoor air inhalation, and dermal contact as the potential routes for human exposure to PFAAs. The aim of this study was to assess the level of PFAAs in the serum samples of a general population in a specific region in Malaysia. Using 219 serum samples collected from residents of Klang Valley, Malaysia, the levels of nine PFAAs were analyzed using liquid chromatography-tandem mass spectrometry. In addition, questionnaire surveys on the dietary habits and lifestyles of the subjects were conducted. The results showed that PFAA concentrations of up to 32.57 ng/mL were detected in all serum samples. In 82.6% of the participants, at least seven PFAAs were detected in the serum samples, with perfluorooctanesulfonic acid being the predominant PFAA (median = 8.79 ng/mL). In the adjusted regression model, the concentrations of most PFAAs were higher in men than in women and positively correlated with age, although body mass index and smoking were not significantly associated with the serum PFAA concentrations. Taking into consideration the lifestyle variables, significant associations were found between nonstick cookware and perfluorononanoic acid, between dental floss and cosmetics and perfluorodecanoic acid (PFDA), and between leather sofa and perfluoroundecanoic acid (PFUnDA). Besides, consumption of beef was significantly associated with increased levels of serum PFUnDA, whereas consumption of lamb and chicken eggs was negatively associated with the serum levels of PFUnDA and PFDA, respectively. |
| Databáze: | OpenAIRE |
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