MMPs in learning and memory and neuropsychiatric disorders
Autor: | Anna Beroun, Leszek Kaczmarek, Barbara Pijet, Piotr Michaluk, Marzena Stefaniuk, Shiladitya Mitra |
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Rok vydání: | 2019 |
Předmět: |
Proteases
Dendritic spine Autism Addiction Review Biology Matrix metalloproteinase Extracellular matrix 03 medical and health sciences Cellular and Molecular Neuroscience Memory medicine Animals Humans Learning Molecular Biology Neuroinflammation Pharmacology 0303 health sciences Epilepsy Neuronal Plasticity Cell adhesion molecule Mental Disorders 030302 biochemistry & molecular biology Brain Tissue Inhibitor of Metalloproteinases Cell Biology medicine.disease Matrix Metalloproteinases Fragile X syndrome Synaptic plasticity Schizophrenia Molecular Medicine Neuroscience Behavioral training |
Zdroj: | Cellular and Molecular Life Sciences |
ISSN: | 1420-9071 1420-682X |
Popis: | Matrix metalloproteinases (MMPs) are a group of over twenty proteases, operating chiefly extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as well as cytokines and growth factors. By virtue of their expression and activity patterns in animal models and clinical investigations, as well as functional studies with gene knockouts and enzyme inhibitors, MMPs have been demonstrated to play a paramount role in many physiological and pathological processes in the brain. In particular, they have been shown to influence learning and memory processes, as well as major neuropsychiatric disorders such as schizophrenia, various kinds of addiction, epilepsy, fragile X syndrome, and depression. A possible link connecting all those conditions is either physiological or aberrant synaptic plasticity where some MMPs, e.g., MMP-9, have been demonstrated to contribute to the structural and functional reorganization of excitatory synapses that are located on dendritic spines. Another common theme linking the aforementioned pathological conditions is neuroinflammation and MMPs have also been shown to be important mediators of immune responses. |
Databáze: | OpenAIRE |
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