Testosterone therapy, thrombophilia, and hospitalization for deep venous thrombosis–pulmonary embolus, an exploratory, hypothesis-generating study
| Autor: | Atif Hassan, Ahsan Hafeez, Ping Wang, Charles J. Glueck, Joel Friedman |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Hormone Replacement Therapy Thrombophilia Models Biological Polymerase Chain Reaction Gastroenterology Risk Factors Internal medicine medicine Humans Testosterone cardiovascular diseases Protein S deficiency Prospective cohort study Homocysteine business.industry Thrombosis General Medicine Middle Aged medicine.disease PULMONARY EMBOLUS Venous thrombosis Immunoglobulin M Immunoglobulin G Warfarin Pulmonary Embolism Familial thrombophilia business |
| Zdroj: | Medical Hypotheses. 84:341-343 |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2015.01.020 |
| Popis: | Our hypothesis was that testosterone therapy (TT) interacts with previously undiagnosed thrombophilia-hypofibrinolysis, leading to hospitalization for deep venous thrombosis (DVT)-pulmonary emboli (PE). We determined the prevalence of DVT-PE associated with TT 147 men hospitalized in the last 12 months for DVT-PE. Of the 147 men, 2 (1.4%) had TT before and at the time of their DVT-PE. Neither had risk factors for thrombosis. Neither smoked. Case #1 (intramuscular T 50mg/week) had 2 PE, 6 and 24 months after starting TT. DVT-PE in case #2 (T gel 100mg/day) occurred 24 months after starting T. Both men were found to have previously undiagnosed familial thrombophilia (protein S deficiency, homocysteinemia, high Factor VIII). In case #2, on 100mg T gel/day, serum estradiol was high, 51 pg/ml (upper normal limit 42.6 pg/ml). At least 1.4% of men hospitalized for DVT-PE were on TT and had previously undiagnosed thrombophilia, suggesting a thrombotic interaction between exogenous T and thrombophilia-hypofibrinolysis. Given the increasing use of TT, our preliminary findings should facilitate design of a much-needed, multi-center, prospective study of pro-thrombotic interactions between T therapy and thrombophilia for subsequent thrombotic events including DVT-PE. |
| Databáze: | OpenAIRE |
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