Low- and high-risk non-T non-B and T-cell acute lymphoid leukemia (ALL) in childhood: Different duration of remission and survival
| Autor: | Wyss M, Andreas Hirt, Berchtold W, Paul Imbach, O. Tönz, R P Zurbrügg, Andreas Morell, C. Baumgartner, H. P. Wagner, E. Gugler, E. Gautier |
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| Rok vydání: | 1981 |
| Předmět: |
Risk
Cancer Research medicine.medical_specialty Adolescent T-Lymphocytes T cell Remission Spontaneous Observation period Receptors Antigen B-Cell Gastroenterology Leukocyte Count Internal medicine Surface marker medicine Asparaginase Humans Child Cyclophosphamide B-Lymphocytes Mercaptopurine business.industry Intensive treatment Complete remission First remission Mediastinal mass Prognosis Leukemia Lymphoid Surgery Methotrexate Acute lymphoid leukemia medicine.anatomical_structure Oncology Vincristine Pediatrics Perinatology and Child Health Prednisone Drug Therapy Combination business |
| Zdroj: | Medical and Pediatric Oncology. 9:309-317 |
| ISSN: | 1096-911X 0098-1532 |
| Popis: | In a prospective, nonrandomized trial clinical (initial WBC and chest film) and immunological (surface immunoglobulin and rosetting with pretreated sheep red blood cells) criteria were used to stratify 69 children with previously untreated acute lymphoid leukemia (ALL). Forty of 61 evaluable patients had low-risk ALL (initial WBC less than or equal to 20,000/mm3, no mediastinal mass) and were treated less intensively. Twenty-one of 61 patients had high-risk ALL (initial WBC greater than 20,000/mm3 and/or mediastinal mass) and were treated more intensively. Of the high-risk patients 15 had non-T non-B and 6 T ALL. Sixty of 61 patients went into complete remission. After a median observation period of 27 months, 32 of 40 low-risk, 7 of 14 high-risk non-T non-B, and none of 6 high-risk T ALL patients were in continuous first remission. Thirty-six of 40 low-risk, 9 of 15 high-risk non-T non-B, and none of 6 T ALL patients were alive. Despite more intensive treatment, the duration of remission and the survival were significantly shorter in the high-risk than in the low-risk patients. Among the high-risk ALL, non-T non-B ALL did better than T ALL. |
| Databáze: | OpenAIRE |
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