Aluminum and iron can be deposited in the calcified matrix of bone exostoses
| Autor: | Didier Moukoko, Jean-Marie Frin, Vincent Steiger, Patrick Le Nay, Charlotte De Bodman, Daniel Chappard, Nicolas Henric, Guillaume Mabilleau |
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| Přispěvatelé: | Groupe d'Études Remodelage Osseux et bioMatériaux (GEROM), Université d'Angers (UA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Osteochondroma Adolescent Medullary cavity Iron Hereditary multiple exostoses [SDV]Life Sciences [q-bio] Bone Matrix chemistry.chemical_element Mineralogy Calcium Biochemistry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance Aluminium medicine Humans Child Exostoses Exostosis Hemochromatosis Aged 030304 developmental biology 0303 health sciences Hyaline cartilage Middle Aged medicine.disease 3. Good health medicine.anatomical_structure chemistry Case-Control Studies Child Preschool Female 030217 neurology & neurosurgery Aluminum |
| Zdroj: | Journal of Inorganic Biochemistry Journal of Inorganic Biochemistry, Elsevier, 2015, 152, pp.174-9. ⟨10.1016/j.jinorgbio.2015.09.008⟩ |
| ISSN: | 0162-0134 |
| DOI: | 10.1016/j.jinorgbio.2015.09.008⟩ |
| Popis: | International audience; Exostosis (or osteochondroma) is the most common benign bone tumor encountered in children and adults. Exostoses may occur as solitary or multiple tumors (in the autosomal syndromes of hereditary multiple exostoses). Exostoses are composed of cortical and medullary bone covered by an overlying hyaline cartilage cap. We have searched iron (Fe) and aluminum (Al) in the matrix of cortical and trabecular bone of 30 patients with exostosis. Al3+and Fe3+are two cations which can substitute calcium in the hydroxyapatite crystals of the bone matrix. The bone samples were removed surgically and were studied undecalcified. Perls' Prussian blue staining (for Fe) and solochrome azurine B (for Al) were used on the histological sections of the tumors. Al3+was detected histochemically in 21/30 patients as linear bands deposited by the osteoblasts. Fe3+was detected in 10 out of these 21 patients as linear bands in the same locations. Fe3+and Al3+were not identified in the bone matrix of a control group of 20 osteoporotic patients. Energy X-ray Dispersive Spectrometry failed to identify Fe and Al in bone of these tumors due to the low sensitivity of the method. Wavelength Dispersive Spectrometry identified them but the concentrations were very low. Histochemistry appears a very sensitive method for Fe3+and Al3+in bone.The presence of these two metals in the exostoses advocates for a disturbed metabolism of osteoblasts which can deposit these metals into the bone matrix, similar to which is observed in case of hemochromatosis with Fe3+. |
| Databáze: | OpenAIRE |
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