| Autor: |
Jean-Philippe Coppé, Laura J. van ‘t Veer, Lamorna Brown-Swigart, Evelyn Pei Rong Lee, Aleksandr Pankov, Christina Yau, Denise M. Wolf, R. Hannes Niedner, Zhongzhong Chen, Aleksandra Olow |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22408986.v1 |
| Popis: |
Phospho-reactome curation workflow (S1); Proteins catalogued in PhosphoAtlas correspond to a unique subset of Protein-Protein Interactions, defined by their active, proven function in phospho-catalytic events (S2); Comparative connectivity between kinases, substrates and HPS's (S3); Most highly connected kinases and substrates (S4); Comparison between the number of enzyme - substrate pairs and the number of kinase - HPS - substrate connections across kinase subfamilies (S5); Disease ontology profile of AKT phospho-circuits (S6); Connectivity of AKT proteins to their upstream and downstream phospho-protein circuits (S7); Catalytic circuitry of AKT1 kinase: an expandable network of enzymatic interaction derived from mutation-prone phospho-target sites (S8); Identification of substrate proteins that are most affected by cancer-mutated peptides, and substrates that are not subject to alterations of their phospho-target sites (S9); Distribution and classification of SNP-altering target sites (S10); Heptameric target variants affecting phosphorylation sites mapped to COSMIC-curated tissue pathologies (S11); Identification of kinases impacted by cancer-mutations that alter their phosphorylatable target sites (S12); Map of the tumor kinome (S13, S14); Examples of kinase and substrate sub-networks, and the differential impact of tumor mutations on their phospho-signaling circuits (S15, S16, S17). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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