Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins
| Autor: | Tae Sung Kim, Jae Woon Lee, Seung-Whan Kim, Youn Sung Kim, Han Jong Kim, Dong Ju Jung, Jae Hong Kim, Soo Kyung Lee |
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| Rok vydání: | 2001 |
| Předmět: |
Transcriptional Activation
Serum Response Factor Cancer Research genetic structures Receptors Retinoic Acid medicine.drug_class Retinoic acid Tretinoin Biology Transactivation chemistry.chemical_compound Nuclear Receptor Coactivator 1 Serum response factor Coactivator Genetics medicine Animals Humans Retinoid Molecular Biology Transcription factor Alitretinoin Cells Cultured Histone Acetyltransferases Models Genetic Nuclear Proteins DNA-binding domain musculoskeletal system eye diseases Rats DNA-Binding Proteins Nuclear receptor chemistry embryonic structures Trans-Activators cardiovascular system Cancer research E1A-Associated p300 Protein Cell Division HeLa Cells Transcription Factors |
| Zdroj: | Oncogene. 20:6638-6642 |
| ISSN: | 1476-5594 0950-9232 |
| Popis: | Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further demonstrate that the repression may involve retinoid-dependent competition for a limiting amount of SRC-1 and p300 between SRF and retinoid receptors. We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF. |
| Databáze: | OpenAIRE |
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