Physiology, pharmacology and plasticity at the inner hair cell synaptic complex

Autor: Jing Wang, Guy Rebillard, Jérôme Ruel, Jean-Luc Puel, Michel Eybalin, Ruth Lloyd, Rémy Pujol
Přispěvatelé: Physiopathologie et thérapie des déficits sensoriels et moteurs, Université Montpellier 2 - Sciences et Techniques (UM2)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Montpellier 1 (UM1), Hamel, Christian
Rok vydání: 2007
Předmět:
MESH: Cell Differentiation
Time Factors
Amino Acid Transport System X-AG
Efferent
Glutamic Acid
AMPA receptor
Neurotransmission
Ribbon synapse
MESH: Synapses
chemistry.chemical_compound
MESH: Cell Proliferation
MESH: Ear Diseases
Excitatory Amino Acid Agonists
medicine
Animals
Humans
Regeneration
MESH: Animals
MESH: Neuronal Plasticity
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Receptors
AMPA
Ear Diseases
Neurotransmitter
Cochlear Nerve
Cell Proliferation
MESH: Humans
MESH: Cochlear Nerve
Hair Cells
Auditory
Inner
Neuronal Plasticity
Chemistry
MESH: Time Factors
MESH: Regeneration
Cochlear nerve
Cell Differentiation
MESH: Glutamic Acid
Sensory Systems
MESH: Hair Cells
Inner
MESH: Evoked Potentials
Auditory
medicine.anatomical_structure
MESH: Receptors
AMPA
Synapses
Evoked Potentials
Auditory
NMDA receptor
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
MESH: Amino Acid Transport System X-AG
Hair cell
MESH: Excitatory Amino Acid Agonists
Neuroscience
Zdroj: Hearing Research
Hearing Research, Elsevier, 2007, 227 (1-2), pp.19-27. ⟨10.1016/j.heares.2006.08.017⟩
ISSN: 0378-5955
DOI: 10.1016/j.heares.2006.08.017
Popis: This report summarizes recent neuropharmacological data at the IHC afferent/efferent synaptic complex: the type of Glu receptors and transporter involved and the modulation of this fast synaptic transmission by the lateral efferents. Neuropharmacological data were obtained by coupling the recording of cochlear potentials and single unit of the auditory nerve with intra-cochlear applications of drugs (multi-barrel pipette). We also describe the IHC afferent/efferent functioning in pathological conditions. After acoustic trauma or ischemia, acute disruption of IHC-auditory dendrite synapses are seen. However, a re-growth of the nerve fibres and a re-afferentation of the IHC were completely done 5 days after injury. During this synaptic repair, multiple presynaptic bodies were commonly found, either linked to the membrane or "floating" in ectopic positions. In the meantime, the lateral efferents directly contact the IHCs. The demonstration that NMDA receptors blockade delayed the re-growth of neurites suggests a neurotrophic role of NMDA receptors in pathological conditions.
Databáze: OpenAIRE
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