Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

Autor:	Zeng-Fei Pei, Dehai Li, Hai-Xue Pan, Yinhua Lu, Lei Li, Weihong Jiang, Yue Yin, Gong-Li Tang, Min-Jie Yang, Xiao-Hong Jian
Rok vydání:	2018
Předmět:	0301 basic medicine Cell Survival Antineoplastic Agents Streptomyces coelicolor Hybrid compound Peptides Cyclic 01 natural sciences Biochemistry 03 medical and health sciences Cell Line Tumor Neoplasms Gene cluster Humans Amino Acid Sequence Physical and Theoretical Chemistry Oxazoles Antitumor activity 010405 organic chemistry Chemistry Organic Chemistry Streptomyces Biosynthetic Pathways 0104 chemical sciences 030104 developmental biology Genes Bacterial Multigene Family Yield (chemistry) Heterologous expression Genetic Engineering
Zdroj:	Organic & Biomolecular Chemistry. 16:9373-9376
ISSN:	1477-0539 1477-0520
DOI:	10.1039/c8ob02665c
Popis:	Using a highly effective heterologous expression system, the YM-216391 (1) biosynthetic gene cluster was engineered to yield aurantizolicin (2) and the hybrid compound 3. Both of these compounds were isolated and fully structurally characterised and the bioactivity was evaluated. The results indicate that compound 3 exhibits significantly improved antitumor activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a38dc13c78e535b312662836d6c556 https://doi.org/10.1039/c8ob02665c Zobrazit plný text záznamu