Serotonergic antidepressants and perioperative bleeding risk: a systematic review
| Autor: | Artin A. Mahdanian, Soham Rej, Simon L. Bacon, Karl J. Looper, Kim L. Lavoie, Deniz Ozdin |
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| Rok vydání: | 2014 |
| Předmět: |
Risk
medicine.medical_specialty Blood transfusion medicine.medical_treatment MEDLINE Blood Loss Surgical Hemorrhage Serotonergic behavioral disciplines and activities mental disorders medicine Humans Pharmacology (medical) Blood Transfusion Adverse effect Intensive care medicine Perioperative Period Abnormal bleeding business.industry General Medicine Perioperative Odds ratio Antidepressive Agents Systematic review business Selective Serotonin Reuptake Inhibitors |
| Zdroj: | Expert opinion on drug safety. 13(6) |
| ISSN: | 1744-764X |
| Popis: | Serotonergic antidepressants (SAds) are known to increase bleeding events, with a number of recent studies investigating this risk in surgical settings. Our main objective was to synthesize the current evidence to evaluate the clinical importance of SAd-related bleeding risk in the perioperative period.A systematic review of MEDLINE, Embase and PsychINFO until November 2013 was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. We examined the risk of perioperative bleeding adverse events in SAd users in comparison to controls.A total of 13 relevant studies were identified across a broad variety of surgical procedures. SAds were associated with an increased risk of perioperative bleeding (odds ratios [ORs] = 1.21 - 4.14) and blood transfusions (ORs = 0.93 - 3.71).SAds are associated with increased perioperative bleeding events, particularly abnormal bleeding and blood transfusions. From a clinical perspective, the potential bleeding risks of SAds in surgical settings need to be carefully weighed against their psychiatric benefits. Future research will need to investigate potential strategies to mitigate SAd-related bleeding risk in the surgical context. |
| Databáze: | OpenAIRE |
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