Corpus Callosum Structure is Topographically Correlated with the Early Course of Cognition and Depression in Alzheimer's Disease

Autor: Claudia Cacciari, Fabrizio Piras, Margherita Di Paola, Carlo Caltagirone, Gianfranco Spalletta, Maria Donata Orfei, Owen R. Phillips
Rok vydání: 2015
Předmět:
Male
Neuropsychological Tests
Corpus callosum
Multimodal Imaging
Corpus Callosum
Cognition
80 and over
Cognitive domain
Longitudinal Studies
first diagnosed AD
Depression (differential diagnoses)
Aged
80 and over
medicine.diagnostic_test
Depression
General Neuroscience
General Medicine
Middle Aged
diffusion tensor imaging
Magnetic Resonance Imaging
Psychiatry and Mental health
Clinical Psychology
Disease Progression
Cardiology
Mini-Mental State Examination
mean diffusivity
Female
Settore MED/26 - Neurologia
Psychology
fractional anisotropy
mild Alzheimer's disease
medicine.medical_specialty
Splenium
drug-free
Alzheimer Disease
Internal medicine
Fractional anisotropy
medicine
voxel-based morphometry
Humans
structural MRI
Aged
corpus callosum
depression
diffusivity
neuropsychiatric symptoms
volume
Diffusion Tensor Imaging
Psychiatric Status Rating Scales
Mini–Mental State Examination
Voxel-based morphometry
Geriatrics and Gerontology
Neuroscience
Diffusion MRI
Zdroj: Journal of Alzheimer's Disease. 45:1097-1108
ISSN: 1875-8908
1387-2877
DOI: 10.3233/jad-142895
Popis: Corpus callosum (CC) abnormalities may cause cognitive and neuropsychiatric complications due to reduced hemispheric integration. Over a one-year period, we investigated whether the CC structure of 20 patients with mild Alzheimer's disease (AD) was linked to the evolution of cognitive and neuropsychiatric symptoms. We also investigated whether this anatomical-clinical relationship was localized topographically on the CC by combining voxel-based morphometry and diffusion tensor imaging approaches. We assessed patients' global cognitive deterioration and neuropsychiatric symptoms with the Mini-Mental State Examination and the Neuropsychiatric Inventory. Increased global cognitive deterioration during the early course of AD was significantly related to reduced white matter density (p = 0.004) and fractional anisotropy (FA) (p = 0.012) and increased mean diffusivity (MD) (p = 0.017) at the level of the CC isthmus/splenium. Further, increased depression severity was significantly related to reduced FA (p = 0.008) and increased MD (p = 0.018) at the level of the CC rostrum. These results indicate that changes in early myelinated CC fibers, which subserve the lateral temporal and parietal cortices and are less vulnerable to damage, may be related to cognitive impairment. Furthermore, changes in late myelinated CC fibers, which connect the orbitofrontal cortices and are more vulnerable to damage, may be related to the earliest neuropsychiatric symptoms of AD, such as depression.
Databáze: OpenAIRE
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