Push-pull mechanism for lipid raft formation
| Autor: | Trevor A. Daly, Martin R. Krause, Paulo F. Almeida, Steven L. Regen |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Molecular Structure
Stereochemistry Cholesterol Cell Membrane technology industry and agriculture Lipid raft formation Surfaces and Interfaces Condensed Matter Physics chemistry.chemical_compound Membrane Eukaryotic Cells Membrane Microdomains chemistry Phase (matter) Electrochemistry Quantitative assessment Phosphatidylcholines lipids (amino acids peptides and proteins) General Materials Science POPC Spectroscopy Push pull Eukaryotic cell |
| Zdroj: | Langmuir : the ACS journal of surfaces and colloids. 30(12) |
| ISSN: | 1520-5827 |
| Popis: | A quantitative assessment has been made of the interaction between exchangeable mimics of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and cholesterol in the liquid-ordered (l0) and the liquid-disordered (ld) states using the nearest-neighbor recognition (NNR) method. This assessment has established that these lipids mix ideally in the l0 phase (i.e., they show no net attraction or repulsion toward each other) but exhibit repulsive interactions in the ld phase. The implications of these findings for the interactions between unsaturated phospholipids and cholesterol in eukaryotic cell membranes are briefly discussed. |
| Databáze: | OpenAIRE |
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