Developmental toxicity of orally administered technical dimethoate in rats
Autor: | Tarek Karkour, Ahmed El Okazy, Amina T. Farag |
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Rok vydání: | 2006 |
Předmět: |
Male
Embryology medicine.medical_specialty Health Toxicology and Mutagenesis Developmental toxicity Administration Oral Biology Toxicology chemistry.chemical_compound Fetus Pregnancy Oral administration Internal medicine medicine Animals Dimethoate Body Weight Organophosphate Maternal effect Abnormalities Drug-Induced Feeding Behavior Organ Size Rats Inbred F344 Teratology Rats Endocrinology chemistry Toxicity Acetylcholinesterase Gestation Female Developmental Biology |
Zdroj: | Birth Defects Research Part B: Developmental and Reproductive Toxicology. 77:40-46 |
ISSN: | 1542-9741 1542-9733 |
Popis: | BACKGROUND: Dimethoate (O,O-dimethyl-S-(N-methylcarbamoyl-methyl) phosphorodithioate), an organophosphate insecticide, was examined for its potential to produce developmental toxicity in rats after oral administration. METHODS: Pregnant Fischer 344 rats were given sublethal doses of 0 (corn oil), 7, 15, and 28 mg/kg/day dimethoate by gavage on gestation days (GD) 6–15. Maternal effects in 15 and 28 mg/kg/day dose groups included cholinergic signs such as tremors, diarrhea, weakness, and salivation, and depression in the maternal and fetal brain acetylcholinesterase (AChE) activities. Other maternal toxicity that included reduction in body weight and feed consumption was observed only in the treated group of 28 mg/kg/day. No maternal toxicity was apparent in the 7 mg/kg/day dose group. RESULTS: Maternal exposure to dimethoate during organogenesis significantly affected the number of live fetuses, early resorption, and mean fetal weight in the 28 mg/kg/day dose group. No external, visceral, and skeletal abnormalities were observed in any of the treated groups compared to the control. CONCLUSIONS: On the basis of the present results dimethoate can produce clinical signs of toxicity and significant inhibition of the maternal and fetal AChE activities in dose groups of 15 and 28 mg/kg/day and showed fetotoxicity without teratogenic effects at 28 mg/kg/day. Birth Defects Res (Part B) 77:40–46, 2006. © 2006 Wiley-Liss, Inc. |
Databáze: | OpenAIRE |
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