Indications for the Use of Proton Pump Inhibitors for Stress Ulcer Prophylaxis and Peptic Ulcer Bleeding in Hospitalized Patients
Autor: | Karen Clarke, Nicole Adler, Alexander Sun, Emily Pherson, Arjun Gupta, Deepak Agrawal, Sarguni Singh, Suchita Shah Sata, Frank M. Volpicelli, Dimpal Bhakta, Amit K. Pahwa, Hyung J. Cho |
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Rok vydání: | 2022 |
Předmět: |
Peptic Ulcer
medicine.medical_specialty Gastrointestinal bleeding medicine.drug_class Proton-pump inhibitor Disease Gastroenterology Hypomagnesemia Internal medicine medicine Humans Stomach Ulcer Ulcer business.industry Stress ulcer Acute kidney injury Proton Pump Inhibitors General Medicine Clostridium difficile medicine.disease digestive system diseases Duodenal Ulcer Acute Disease Gastrointestinal Hemorrhage business Kidney disease |
Zdroj: | The American Journal of Medicine. 135:313-317 |
ISSN: | 0002-9343 |
Popis: | Proton pump inhibitors are widely used throughout the world for the treatment of gastrointestinal disorders that are related to acid secretion, such as peptic ulcer disease and dyspepsia. Another common indication for proton pump inhibitors is stress ulcer prophylaxis. Proton pump inhibitors have proven efficacy for the treatment of acid-related gastrointestinal disorders, but there is concern that their use may be associated with the development of significant complications, such as fractures, Clostridium difficile infection, acute kidney injury, chronic kidney disease, and hypomagnesemia. Proton pump inhibitors are overused in the hospital setting, both for stress ulcer prophylaxis and gastrointestinal bleeding, and then they are often inappropriately continued after discharge from the hospital. This narrative review article outlines the evidence surrounding appropriate proton pump inhibitor use for stress ulcer prophylaxis and peptic ulcer bleeding. |
Databáze: | OpenAIRE |
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