Ultrastructural effects of diabetes in the right atrium cardiomyocytes of elderly Wistar rats
| Autor: | Nicolas Da Costa-Santos, Kemily Loren Barros Chucata, Natalie Souza de Andrade, Laura Beatriz Mesiano Maifrino, Ricardo Aparecido Baptista Nucci, Romeu Rodrigues de Souza, Walkyria Villegas Magalhães, Igor Roberto Dias, Hunter Douglas de Souza Lima |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Diabetic Cardiomyopathies 030204 cardiovascular system & hematology Mitochondrion Streptozocin Pathology and Forensic Medicine Diabetes Mellitus Experimental 03 medical and health sciences symbols.namesake 0302 clinical medicine Diabetes mellitus Internal medicine Natriuretic Peptide Brain Medicine Distribution (pharmacology) Animals Myocytes Cardiac Heart Atria Rats Wistar business.industry Endoplasmic reticulum Age Factors General Medicine Golgi apparatus medicine.disease Streptozotocin Up-Regulation 030104 developmental biology Endocrinology medicine.anatomical_structure symbols Ultrastructure Right atrium Cardiology and Cardiovascular Medicine business Atrial Natriuretic Factor medicine.drug |
| Zdroj: | Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 45 |
| ISSN: | 1879-1336 |
| Popis: | The present study aimed to evaluate the effects of diabetes on quantitative parameters of right atrial cardiomyocytes of elderly rats. Wistar rats (14 months of age) were divided into two groups: streptozotocin-diabetic rats (DG) and control rats (CG). The groups were sacrificed at 16 months. Ultrafine sections of the right atrium were analyzed by electron microscopy. In elderly diabetic animals, histograms of the frequency distribution of natriuretic peptides according to their size showed increased number of small and medium peptides in relation to large peptides, which increased its numerical density leading to a decrease in the mean diameter of both natriuretic peptides. However, elderly diabetic animals remained normotensive. No significant difference was observed between the groups for the volume density of mitochondria, endoplasmic reticulum, and Golgi apparatus. In conclusion, elderly diabetic rats showed increased functional activity of atrial cardiomyocytes with greater production of natriuretic peptides in association with a quantitative maintenance of cytoplasmic components. |
| Databáze: | OpenAIRE |
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