Relationship of natural incidence and radiosensitivity for bone cancer in dogs
| Autor: | X. J. Li, Scott C. Miller, L. Shabestari, Ray D. Lloyd, Webster S. S. Jee, S. Mori, Glenn N. Taylor, C.W. Mays |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Pathology Neoplasms Radiation-Induced Epidemiology Health Toxicology and Mutagenesis Bone Neoplasms Biology medicine.disease_cause Malignancy Beagle Radiation Tolerance Dogs Species Specificity Risk Factors Internal medicine medicine Animals Radiology Nuclear Medicine and imaging Radiosensitivity Dog Diseases Bone cancer Incidence (epidemiology) Incidence Cancer Sarcoma medicine.disease Skeleton (computer programming) Plutonium Endocrinology Carcinogenesis Radium |
| Zdroj: | Health physics. 73(4) |
| ISSN: | 0017-9078 |
| Popis: | A comparison of the risk coefficients for {sup 239}Pu- or {sup 226}Ra-induced bone cancer in two canine breeds, one with a relatively low (beagle) and the other with a very high (St. Bernard) natural incidence, indicated only slightly higher risk in the giant breed. The differences in risk for skeletal malignancy in {sup 239}Pu and {sup 226}Ra dogs were nonsignificant (p > 0.05). Likewise, the values of the {sup 239}Pu:{sup 226}Ra {open_quotes}toxicity ratios{close_quotes} for these respective breeds, using bone cancer as the endpoint, were not significantly different at the 0.05 level. The anatomical distribution of the radiation-induced bone tumors tended to be a function of both the bone mass and the skeletal distribution of the radio nuclide, not the site of predilection for naturally occurring bone neoplasia. Although the etiology of the higher natural incidence of bone cancer in the St. Bernard was not determined, several possible factors, including a higher osteoblastic activity level in the St. Bernards, are presented. These data suggest that making extrapolations of radiation-induced bone cancer risk from animals to humans is valid. 26 refs., 5 tabs. |
| Databáze: | OpenAIRE |
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