Modelling the restoration of activity in a biological neural network
| Autor: | Jannetta S. Steyn, Peter Andras, Filipa dos Santos |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
QA75
0301 basic medicine Computer science business.industry Stomatogastric ganglion QA76 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Order (biology) Biological neural network Neural system Artificial intelligence QA business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | IJCNN International Joint Conference on Neural Networks |
| Popis: | Understanding the mechanisms of restoration of activity in biological neural systems following exposure to damage is key for design of future neuro-prosthetic devices and restorative treatments. The pyloric rhythm network within the crustacean stomatogastric ganglion is a biological neural system that shows spontaneous restoration of activity following the stopping of inputs from higher control ganglia. We model the restoration of the activity in this network using conductance-based models of neurons and the alteration of conductance parameters of the model. Our analysis shows that this approach works only if some of the conductance values remain constrained following the stopping of higher inputs. Our model also shows that in order to model the restoration of the activity in this network it is not necessary to rely on complicated alterations of the mechanisms of Calcium ionic currents in the model, which was proposed previously. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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