Effect of small doses of ethylene glycol monomethyl ether on the acetylcholinesterase and delta-aminolevulinic acid dehydratase activity in erythrocytes, blood and bone marrow of rats
| Autor: | Tabarowski Z, Lazewska M, Zbigniew Dabrowski |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Erythrocytes Aché Health Toxicology and Mutagenesis 010501 environmental sciences Toxicology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Bone Marrow Internal medicine medicine Animals Delta-aminolevulinic acid dehydratase activity Rats Wistar 0105 earth and related environmental sciences Whole blood chemistry.chemical_classification Hematologic Tests 030102 biochemistry & molecular biology Dose-Response Relationship Drug Public Health Environmental and Occupational Health Porphobilinogen Synthase Acetylcholinesterase language.human_language Rats Ethylene glycol monomethyl ether Endocrinology Enzyme medicine.anatomical_structure Biochemistry chemistry Dehydratase language Solvents Ethylene Glycols Bone marrow |
| Zdroj: | Toxicology and industrial health. 9(4) |
| ISSN: | 0748-2337 |
| Popis: | The effect of small doses of ethylene glycol monomethyl ether (EGMME) on the activity of acetylcholinesterase (ACHE) in erythrocytes and whole blood as well as on the Δ-aminolevulinic acid dehydratase (ALA-D) in blood and bone marrow was studied in Wistar rats. Significant reduction in the activity of both enzymes was noted three days after ip administration of 200 mg/kg b.w. EGMME whereas seven days later the activity of both enzymes returned to the control levels. Activity of ALA-D in blood appeared to be most sensitive to EGMME, and reacted even to the lowest dose, which did not significantly alter activity of ACHE or ALA-D in bone marrow. Haematological parameters in all treated groups remained unaltered. |
| Databáze: | OpenAIRE |
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