ASYMMETRIC CELL DIVISION IN C. ELEGANS: Cortical Polarity and Spindle Positioning

Autor:	Carrie R. Cowan, Anthony A. Hyman
Rok vydání:	2004
Předmět:	Cell division Polarity (physics) Cell Polarity Spindle Apparatus Cell Biology Biology Cell biology Microtubule Centrosome Asymmetric cell division Animals Caenorhabditis elegans Cytoskeleton Mitosis Cell Division Developmental Biology Anaphase
Zdroj:	Annual Review of Cell and Developmental Biology. 20:427-453
ISSN:	1530-8995 1081-0706
DOI:	10.1146/annurev.cellbio.19.111301.113823
Popis:	▪ Abstract The one-cell Caenorhabditis elegans embryo divides asymmetrically into a larger and smaller blastomere, each with a different fate. How does such asymmetry arise? The sperm-supplied centrosome establishes an axis of polarity in the embryo that is transduced into the establishment of anterior and posterior cortical domains. These cortical domains define the polarity of the embryo, acting upstream of the PAR proteins. The PAR proteins, in turn, determine the subsequent segregation of fate determinants and the plane of cell division. We address how cortical asymmetry could be established, relying on data from C. elegans and other polarized cells, as well as from applicable models. We discuss how cortical polarity influences spindle position to accomplish an asymmetric division, presenting the current models of spindle orientation and anaphase spindle displacement. We focus on asymmetric cell division as a function of the actin and microtubule cytoskeletons, emphasizing the cell biology of polarity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19254bf38fd49c90304c4333bc2238d https://doi.org/10.1146/annurev.cellbio.19.111301.113823 Zobrazit plný text záznamu