Neuroendocrine Tumors of the Gastrointestinal Tract
| Autor: | U. Askensten, Victor E. Gould, G. Chejfec, Lars Grimelius, Sture Falkmer |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
endocrine system
medicine.medical_specialty Pathology Esophageal Neoplasms Psammoma body Carcinoid tumors Carcinoid Tumor Biology Neuroendocrine tumors digestive system Pathology and Forensic Medicine Duodenal Neoplasms Stomach Neoplasms Internal medicine medicine Humans Enterochromaffin-like cell Gastrointestinal Neoplasms Gastrin Gastrointestinal tract Jejunal Neoplasms Histocytochemistry Foregut DNA Cell Biology medicine.disease Neurosecretory Systems digestive system diseases Ileal Neoplasms Endocrinology medicine.anatomical_structure Appendiceal Neoplasms Colonic Neoplasms Duodenum |
| Zdroj: | Pathology - Research and Practice. 183:143-154 |
| ISSN: | 0344-0338 |
| DOI: | 10.1016/s0344-0338(88)80042-6 |
| Popis: | Neoplastic proliferations of neuroendocrine cells (NE) may occur throughout the entire GI tract but affect particularly appendix and ileum ("midgut carcinoids"), rectum ("hindgut carcinoids"), as well as stomach and the duodenum ("foregut carcinoids"). Only more exceptionally, they arise in the esophagus, jejunum and colon. The NE tumors encompass a heterogeneous gross and microscopic structural spectrum, ranging from inconspicuous microproliferations ("mucous membrane nevi") to bulky tumor masses. Their growth patterns are usually characteristic and easily recognized. In doubtful cases their NE differentiation becomes established by a characteristic silver affinity, by the ultrastructurally observed presence of characteristic "endocrine" secretion granules, and by immunohistochemically detectable occurrence of "pan-NE markers" (neuron-specific enolase, chromogranins, and synaptophysin), biogenic amines (mainly serotonin), and neurohormonal peptides. Foregut carcinoids usually contain serotonin, gastrin, and somatostatin, midgut carcinoids often only serotonin and tachykinins, whereas the hindgut carcinoids as a rule are multihormonal with a wide spectrum of hormonal peptides, including even insulin. Most GI NE tumors are found in the appendix (50%) and the ileum (30%). Practically all (98%) of the appendiceal NE tumors are benign. They have recently been proposed as arising from apparently Schwann-cell-related NE cells in the submucosa, whereas the ileal--and probably also all the other non-appendiceal NE tumors--are derived from the totipotential cells in epithelial crypts of the mucosa. Among the ileal NE neoplasms a large number can metastasize and result in a fatal outcome. The ability to metastasize is related to the size and to the multiplicity of the primary tumors at the time of initial diagnosis and, to some extent, to their histopathologic growth pattern. Now, some relationship between the prognosis and the cytochemically assessed nuclear DNA content of the NE tumor cells has also been established; not less than about 1/4 to 1/3 seem to be aneuploid. Almost 90% of the rectal carcinoids are benign. Exceptionally, a highly malignant NE neoplasms can arise from the colon/rectum--as well as from the esophagus--composed of NE cells of small and intermediate size. The NE tumors of the stomach are often composed of ECL (enterochromaffin-cell-like) cells; such ECL cell carcinoids are related to atrophic gastritis with pernicious anemia; experimentally, they can be induced by hypergastrinemia in rats. Duodenal carcinoids often contain psammoma bodies and can be associated with neurofibromatosis. |
| Databáze: | OpenAIRE |
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