Apoptosis, ageing and cancer susceptibility
| Autor: | Audrey Ardern-Jones, Doug Easton, Richard Camplejohn, Rosalind A. Eeles, R Gilchrist, Diana Eccles, Diana M. Barnes, E McKenzie-Edwards, Shirley Hodgson, P M Duddy |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Senescence Aging Cancer Research Programmed cell death DNA damage Biology Clinical Breast cancer Neoplasms Odds Ratio medicine Humans Lymphocytes BRCA2 Protein Sex Characteristics BRCA1 Protein apoptosis Cancer Dose-Response Relationship Radiation Odds ratio Middle Aged cancer susceptibility medicine.disease radiation age Oncology Gamma Rays Ageing Apoptosis Immunology Cancer research Female Disease Susceptibility |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6600767 |
| Popis: | We have previously shown that peripheral blood lymphocytes (PBL) from individuals carrying a germline TP53 mutation show a dramatically reduced apoptotic response to radiation. As part of a study of this phenomenon, we also investigated apoptotic response in a series of breast cancer patients lacking TP53 mutations and in a control group of individuals without cancer. There was a significant reduction in mean apoptotic response with increasing age in all groups. These findings are consistent with a number of studies in rodents, which have demonstrated a reduction in DNA damage-induced apoptosis with increasing age. In addition, after adjusting for age, breast cancer patients showed significantly reduced apoptotic responses compared with normal controls (P=0.002). The odds ratio for breast cancer in women with an apoptotic response of35%, compared with women with a response of49%, was 6.42 (95% CI 1.68-24.6). The data further support the hypothesis that a reduction in apoptotic response to DNA damage with increasing age may play a significant role in the age-related increase in cancer. |
| Databáze: | OpenAIRE |
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