The Long Bone Deformity of Osteogenesis Imperfecta III: Analysis of Structural Changes Carried Out with Scanning Electron Microscopic Morphometry
Autor: | Pier Carlo Brunelli, Anna Benetti, Terenzio Congiu, Luigi Magnano, Ugo E. Pazzaglia |
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Rok vydání: | 2013 |
Předmět: |
Bone density
Cortical bone Endocrinology Diabetes and Metabolism Biology Electron Endocrinology Bone Density medicine Deformity Drifting osteon Osteogenesis imperfecta III Osteotomy Scanning electron microscopic morphometry Case-Control Studies Child Child Preschool Female Femur Haversian System Humans Microscopy Electron Scanning Osteogenesis Imperfecta Tibia Scanning Orthopedics and Sports Medicine Preschool Microscopy Anatomy medicine.disease Resorption Radiography medicine.anatomical_structure Osteon Osteogenesis imperfecta medicine.symptom |
Zdroj: | Calcified Tissue International. 93:453-461 |
ISSN: | 1432-0827 0171-967X |
Popis: | The wedges of the mid-diaphyseal osteotomies carried out to correct the femoral and/or tibial native deformity in type III osteogenesis imperfecta (OI III) were used to study the remodeling patterns and lamellar organization at the level of the major deformity. Histology and scanning electron microscopy (SEM) morphology showed abnormal cortical remodeling characterized by the failure to form a cylinder of compact bone with a regular marrow canal. Atypical, flattened, and large resorption lacunae with a wide resorption front on one side and systems of parallel lamellae on the opposite side were observed, resembling those formerly reported as drifting osteons. SEM morphometry documented a higher percentage of nonossified vascular/resorption area (44.3 %) in OI than in controls (13.6 %), a lower density of secondary osteons, and lower values for the parameters expressing the individual osteon size. The mean osteon total area, the mean central canal area, and the mean osteon bone area of two selected, randomized populations of secondary osteons were significantly higher (p |
Databáze: | OpenAIRE |
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