Insulin Lispro Lowers Postprandial Glucose in Prepubertal Children With Diabetes
| Autor: | Morris R. Jenner, Stuart Brink, Martha Spencer, Kusiel Perlman, Hilary Kitson, Rocco L. Brunelle, Larry C. Deeb, John H. Holcombe, Sunita Zalani |
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| Rok vydání: | 2001 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Hypoglycemia Internal medicine Diabetes mellitus Humans Hypoglycemic Agents Insulin Medicine Insulin lispro Child Before Meals Pancreatic hormone Analysis of Variance Type 1 diabetes Meal Cross-Over Studies Insulin Lispro business.industry digestive oral and skin physiology Age Factors Hemoglobin A Postprandial Period medicine.disease Diabetes Mellitus Type 1 Endocrinology Postprandial Child Preschool Pediatrics Perinatology and Child Health Female business medicine.drug |
| Zdroj: | Pediatrics. 108:1175-1179 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.108.5.1175 |
| Popis: | Objective. This study compared the glucose-lowering effect of insulin lispro, given before or after meals, with regular human insulin given before meals in prepubertal children with diabetes. Research Design and Methods. A 3-way crossover, open-label study involving 61 prepubertal children (ages 2.9–11.4 years) with type 1 diabetes. The children were randomly assigned to receive regular human insulin 30 to 45 minutes before meals, insulin lispro within 15 minutes before or immediately after meals, combined with basal insulin. Each treatment lasted 3 months. Hemoglobin A1c levels and home glucose monitoring profiles were measured at the end of each treatment period. Results. Treatment with insulin lispro before breakfast resulted in lower 2-hour postprandial glucose values than regular human insulin (11.7 ± 4.4 mmol/L vs 15.0 ± 5.4 mmol/L). Similarly, insulin lispro given before dinner resulted in lower blood glucose values 2 hours postprandially (8.8 ± 5.0 mmol/L vs 10.8 ± 5.4 mmol/L) than regular human insulin. When insulin lispro was administered after meals, the 2-hour glucose levels were between those seen with either insulin lispro or regular human insulin given before meals. The number and types of adverse events, the rates of hypoglycemia, and the HbA1c levels did not differ among the 3 therapies. Conclusions. In prepubertal children, insulin lispro given before meals is safe and significantly lowers postprandial glucose levels after breakfast and dinner compared with regular human insulin, and insulin lispro given after the meal provides similar benefits as regular human insulin before the meal. |
| Databáze: | OpenAIRE |
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