Diurnal Blood Pressure Variation in Progressive Autonomic Failure
| Autor: | Anton H. van den Meiracker, António Freitas, Arie J. Man in 't Veld, M.J. Lima, João Freitas, Carvalho Mj, Frans Boomsma |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Shy-Drager Syndrome Hemodynamics Blood Pressure Autonomic Nervous System Internal medicine Heart rate Internal Medicine medicine Valsalva maneuver Humans Circadian rhythm Pure autonomic failure business.industry Diurnal temperature variation Middle Aged medicine.disease Circadian Rhythm Autonomic nervous system Endocrinology Blood pressure Female business |
| Zdroj: | Hypertension. 35:892-897 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.35.4.892 |
| Popis: | Abstract —To investigate the role of the autonomic nervous system (ANS) in the generation of the circadian blood pressure (BP) variation, the degree of impairment of the ANS was related to the results of ambulatory BP recordings in 212 patients with progressive autonomic failure due to familial amyloid polyneuropathy. On the basis of BP and/or heart rate (HR) responses to the Valsalva maneuver, 60° head-up tilting, deep-breathing tests, and plasma norepinephrine levels, 4 groups of patients were distinguished. In all patients and in 38 age-matched control subjects, ambulatory BP was monitored. Patients of group I (n=40, aged 32±3 y), with no evidence yet of impairment of their ANS, had circadian BP and HR variations indistinguishable from controls. Patients of group II (n=41, aged 34±5 y) had a variable degree of impairment of their parasympathetic ANS, but their sympathetic ANS was still intact. Twenty-four–hour HR was higher in these patients than in controls (88±11 versus 78±7 bpm, P P |
| Databáze: | OpenAIRE |
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