Modeling Red Blood Cell Viscosity Contrast Using Inner Soft Particle Suspension
| Autor: | Iveta Jančigová, Alžbeta Bohiniková, Ivan Cimrák |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
computational modeling
Work (thermodynamics) Materials science Mechanical Engineering Relative velocity Viscometer Mechanics Article Quantitative Biology::Cell Behavior dissipative particles Viscosity Rheology Control and Systems Engineering viscosity Dissipative system TJ1-1570 Particle rheology Mechanical engineering and machinery Electrical and Electronic Engineering blood cells Conservative force |
| Zdroj: | Micromachines, Vol 12, Iss 974, p 974 (2021) Micromachines Volume 12 Issue 8 |
| Popis: | The inner viscosity of a biological red blood cell is about five times larger than the viscosity of the blood plasma. In this work, we use dissipative particles to enable the proper viscosity contrast in a mesh-based red blood cell model. Each soft particle represents a coarse-grained virtual cluster of hemoglobin proteins contained in the cytosol of the red blood cell. The particle interactions are governed by conservative and dissipative forces. The conservative forces have purely repulsive character, whereas the dissipative forces depend on the relative velocity between the particles. We design two computational experiments that mimic the classical viscometers. With these experiments we study the effects of particle suspension parameters on the inner cell viscosity and provide parameter sets that result in the correct viscosity contrast. The results are validated with both static and dynamic biological experiment, showing an improvement in the accuracy of the original model without major increase in computational complexity. |
| Databáze: | OpenAIRE |
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