Diaphragmatic hernia during treatment of lung cancer harboring an EGFR mutation
| Autor: | Aya Konno-Yamamoto, Osamu Narumoto, Miho Yamaguchi, Yuta Inoue, Makoto Motoyoshi, Takeshi Fukami, Shota Yamamoto, Hirotoshi Matsui, Atsuhisa Tamura |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty omcrep/600 Perforation (oil well) Diaphragmatic breathing Case Report Treatment of lung cancer Microbiology Gastroenterology omcrep/2200 Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Diaphragmatic hernia Hernia Lung cancer business.industry medicine.disease respiratory tract diseases omcrep/1500 030104 developmental biology Infectious Diseases 030220 oncology & carcinogenesis Vomiting Parasitology medicine.symptom business AcademicSubjects/MED00010 |
| Zdroj: | Oxford Medical Case Reports |
| ISSN: | 2053-8855 |
| Popis: | Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are a first-line treatment for patients with nonsmall-cell lung cancer harboring EGFR mutations. We report a 65-year-old Japanese woman with nonsmall-cell lung cancer taking an EGFR-TKI who visited the emergency department with acute nausea and vomiting. Imaging studies demonstrated an incarcerated diaphragmatic hernia. Urgent diagnostic surgery revealed a gap in the diaphragm acting as a hernial orifice, where a metastatic tumor was detected. We consider that regression of the diaphragmatic metastasis by EGFR-TKI therapy resulted in perforation of the diaphragm, causing the diaphragmatic hernia. Gastrointestinal adverse events, e.g. nausea, vomiting and diarrhea, are common during EGFR-TKI treatment. However, this case suggests that in patients with diaphragmatic metastasis, we should consider the rare possibility of diaphragmatic perforation and a subsequent hernia. |
| Databáze: | OpenAIRE |
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