Inhibitory Effects of Citrus hassaku Extract and Its Flavanone Glycosides on Melanogenesis
| Autor: | Kazuya Murata, Kimihisa Itoh, Keitaro Wakabayashi, Noriko Hirata, Megumi Masuda, Hideaki Matsuda, Shunsuke Naruto |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
musculoskeletal diseases
Citrus Antioxidant Ultraviolet Rays DPPH Tyrosinase medicine.medical_treatment Guinea Pigs Pharmaceutical Science Skin Pigmentation Chemical Fractionation Antioxidants Superoxide dismutase Mice chemistry.chemical_compound Cell Line Tumor medicine Animals Glycosides Naringin Cell Proliferation Melanins Pharmacology Neohesperidin chemistry.chemical_classification Ethanol biology Monophenol Monooxygenase Plant Extracts Glycoside Free Radical Scavengers General Medicine Biochemistry chemistry Flavanones Solvents biology.protein Female human activities Flavanone |
| Zdroj: | Biological and Pharmaceutical Bulletin. 32:410-415 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.32.410 |
| Popis: | The 50% ethanolic extract (CH-ext) obtained from the unripe fruit of Citrus hassaku exhibited significant tyrosinase inhibitory activity. The CH-ext showed antioxidant activity, such as superoxide dismutase (SOD)-like activity and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity. Activity-guided fractionation of the CH-ext indicated that flavanone glycoside-rich fractions showed potent tyrosinase inhibitory activity. Further examination revealed that the tyrosinase inhibitory activity and antioxidant activity of the CH-ext were attributable to naringin and neohesperidin, respectively. The CH-ext showed inhibition of melanogenesis without any effects on cell proliferation in cultured murine B16 melanoma cells after glucosamine exposure. The topical application of the CH-ext to the dorsal skin of brownish guinea pigs showed in vivo preventive effects against UVB-induced pigmentation. |
| Databáze: | OpenAIRE |
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