Long-standing, insulin-treated type 2 diabetes patients with complications respond well to short-term resistance and interval exercise training
| Autor: | Hans A. Keizer, Coen D.A. Stehouwer, L.J.C. van Loon, Stephan F. E. Praet, Harm Kuipers, G. Schep, Richard A. M. Jonkers |
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| Přispěvatelé: | RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, RS: NUTRIM - R1 - Metabolic Syndrome, RS: CARIM School for Cardiovascular Diseases, Bewegingswetenschappen, Interne Geneeskunde |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Work medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment Physical exercise Type 2 diabetes Oxygen Consumption Endocrinology Diabetic Neuropathies Internal medicine Diabetes mellitus medicine Humans Hypoglycemic Agents Insulin Muscle Strength Muscle Skeletal Exercise Aged Physical Education and Training Adiponectin business.industry VO2 max General Medicine Middle Aged medicine.disease Confidence interval Treatment Outcome Blood pressure Diabetes Mellitus Type 2 Feasibility Studies business |
| Zdroj: | European Journal of Endocrinology, 158(2), 163-72. BioScientifica Ltd. |
| ISSN: | 0804-4643 |
| Popis: | ObjectiveTo determine the feasibility and the benefits of combined resistance and interval exercise training on phenotype characteristics and skeletal muscle function in deconditioned, type 2 diabetes (T2D) patients with polyneuropathy.DesignShort-term, single-arm intervention trial.MethodsEleven male T2D patients (age: 59.1±7.5 years; body mass index: 32.2±4.0 kg/m2) performed progressive resistance and interval exercise training thrice a week for 10 weeks. Besides primary diabetes outcome measures, muscle strength (MUST), maximal workload capacity (Wmax), whole-body peak oxygen uptake (VO2peak) and muscle oxidative capacity (MUOX), intramyocellular lipid (IMCL) and glycogen (IMCG) storage, and systemic inflammation markers were determined before and after training. Daily exogenous insulin requirements (EIR) and historic individualized EIR were gathered and analysed.ResultsMUST and Wmax increased with 17% (90% confidence intervals 9–24%) and 14% (6–21) respectively. Furthermore, mean arterial blood pressure declined with 5.5 mmHg (−9.7 to −1.4). EIR dropped with 5.0 IU/d (−11.5 to 1.5) compared with baseline. A decline of respectively −0.7 mmol/l (−2.9 to 1.5) and −147 μmol/l (−296 to 2) in fasting plasma glucose and non-esterified fatty acids concentrations were observed following the intervention, but these were not accompanied by changes in VO2peak, MUOX, IMCL or IMCG, and blood glycolysated haemoglobin, adiponectin, tumor necrosis factor-α and/or cholesterol concentrations.ConclusionShort-term resistance and interval exercise training is feasible in deconditioned T2D patients with polyneuropathy and accompanied by moderate improvements in muscle function and blood pressure. Such a specific exercise regimen may provide a better framework for future exercise intervention programmes in the treatment of deconditioned T2D patients. |
| Databáze: | OpenAIRE |
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