Investigating the Role of Relaxin in the Regulation of Airway Fibrosis in Animal Models of Acute and Chronic Allergic Airway Disease
| Autor: | Mimi L.K. Tang, Ishanee Mookerjee, Geoffrey W. Tregear, Natasha R. Solly, Chrishan S. Samuel |
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| Rok vydání: | 2005 |
| Předmět: |
Pathology
medicine.medical_specialty Ovalbumin Pulmonary Fibrosis General Biochemistry Genetics and Molecular Biology Mice Pulmonary Disease Chronic Obstructive History and Philosophy of Science Fibrosis Hypersensitivity medicine Animals Asthma Mice Knockout Basement membrane Relaxin Lung business.industry General Neuroscience respiratory system Airway obstruction medicine.disease respiratory tract diseases Disease Models Animal medicine.anatomical_structure Airway disease Acute Disease Immunology Airway business |
| Zdroj: | Annals of the New York Academy of Sciences. 1041:194-196 |
| ISSN: | 0077-8923 |
| DOI: | 10.1196/annals.1282.029 |
| Popis: | Airway remodeling is a characteristic feature of asthma that leads to chronic irreversible airway obstruction. Fibrosis in the basement membrane region is a hallmark of remodeling in asthma that is not found in other diseases. In the outlined studies, we investigated the relationship between relaxin and airway fibrosis in asthma using acute and chronic models of allergic airway disease. These studies confirm a critical role for relaxin, in the regulation of collagen deposition in the airway/lung in animal models of allergic airway disease. |
| Databáze: | OpenAIRE |
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