SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
| Autor: | Boudewijn J. Krenning, Eric J Meester, Monique R. Bernsen, Frank J. H. Gijsen, K. van der Heiden, Freek J. Beekman, Hence J.M. Verhagen, A. van der Lugt, M. de Jong, Jeffrey P. Norenberg, K van Gaalen, E. de Blois, Hilary E. Barrett, J. de Swart |
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| Přispěvatelé: | Cardiology, Radiology & Nuclear Medicine, Surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Carotid Artery Diseases
Pathology medicine.medical_specialty Single Photon Emission Computed Tomography Computed Tomography medicine.medical_treatment Inflammation 030204 cardiovascular system & hematology medicine.disease_cause 030218 nuclear medicine & medical imaging calcification 03 medical and health sciences 0302 clinical medicine Medicine Humans Radiology Nuclear Medicine and imaging Endarterectomy business.industry Fibrous cap Indium Radioisotopes Calcinosis Histology SPECT/CT medicine.disease Vulnerable plaque Lymphocyte Function-Associated Antigen-1 Plaque Atherosclerotic medicine.anatomical_structure Atheroma inflammation human carotid plaque vulnerable plaque medicine.symptom Ct imaging Cardiology and Cardiovascular Medicine business Biomarkers Calcification |
| Zdroj: | BASE-Bielefeld Academic Search Engine Journal of Nuclear Cardiology, 29(5) Journal of Nuclear Cardiology. Springer New York |
| ISSN: | 1071-3581 |
| Popis: | Background Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers. Methods Human carotid plaque segments, obtained from endarterectomy, were incubated in [111In]In-DOTA-butylamino-NorBIRT ([111In]In-Danbirt), targeting Leukocyte Function-associated Antigen-1 (LFA-1) on leukocytes. By performing SPECT/CT, both inflammation from DANBIRT uptake and calcification from CT imaging were assessed. Plaque phenotype was classified using histology. Results On a total plaque level, comparable levels of calcification volume existed with different degrees of inflammation and vice versa. On a segment level, an inverse relationship between calcification volume and inflammation was evident in highly calcified segments, which classify as fibrocalcific, stable plaque segments. In contrast, segments with little or no calcification presented with a moderate to high degree of inflammation, often coinciding with the more dangerous fibrous cap atheroma phenotype. Conclusion Calcification imaging alone can only accurately identify highly calcified, stable, fibrocalcific plaques. To identify high-risk plaques, with little or no calcification, hybrid imaging of calcification and inflammation could provide diagnostic benefit. |
| Databáze: | OpenAIRE |
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