MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer
| Autor: | Marion Gayral, Jérôme Torrisani, Yannick Delpu, Maël Chalret du Rieu, Pierre Cordelier, Marlène Dufresne, Barbara Bournet, Alix Vignolle-Vidoni, Hubert Lulka, Nicolas Carrere, Janick Selves, Aline Meulle, Naima Hanoun, Sébastien Jo, Marine Humeau, Rosine Guimbaud, Louis Buscail |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty Disease Diagnostic tools Predictive Value of Tests Risk Factors Internal medicine Pancreatic cancer microRNA medicine Advanced disease Biomarkers Tumor Animals Humans Topic Highlight Genetic Testing Early Detection of Cancer Neoplasm Staging business.industry Gastroenterology Cancer General Medicine medicine.disease Gene Expression Regulation Neoplastic Pancreatic Neoplasms MicroRNAs Immunology Adenocarcinoma business Median survival Carcinoma Pancreatic Ductal |
| Popis: | Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma (PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients (80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are desperately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. |
| Databáze: | OpenAIRE |
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