Cytoprotective and genotoxic effects of vitamins K1 and B1 on irinotecan in vitro
| Autor: | Eleni Giarma, Th. Lialiaris, Dionysios Mourelatos, Zoi Mpampali |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Vitamin Mitotic index Health Toxicology and Mutagenesis Sister chromatid exchange Antineoplastic Agents 010501 environmental sciences Pharmacology medicine.disease_cause Irinotecan 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Genetics medicine Mitotic Index Humans heterocyclic compounds Lymphocytes Thiamine Cytotoxicity neoplasms Cells Cultured 0105 earth and related environmental sciences Cell Proliferation Mutagenicity Tests Vitamin K 1 digestive system diseases In vitro Drug Combinations 030104 developmental biology chemistry Sister Chromatid Exchange Camptothecin Genotoxicity medicine.drug |
| Zdroj: | Mutation research. Genetic toxicology and environmental mutagenesis. 837 |
| ISSN: | 1879-3592 |
| Popis: | Cultured human lymphocytes were treated with vitamins K1 and B1, potential anticancer agents, either alone or in combination with irinotecan, a semisynthetic analogue of camptothecin. The frequency of sister chromatid exchanges (SCEs) was measured as an indicator of genotoxicity and the proliferation rate index (PRI) and mitotic index (MI) was measured as indicators of cytostatic effect. Vitamin K1 alone did not induce SCEs at the concentrations tested and combined with irinotecan does not increase SCE rates induced by irinotecan alone. Vitamin B1 significantly increased SCEs and, in combination with irinotecan, increased rates further (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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