Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of Gabon
| Autor: | Rodrigue Bikangui, Moustapha Nzamba Maloum, Elie G. Rossatanga, Thirumalaisamy P. Velavan, Steffen Borrmann, Bertrand Lell, Jean-Bernard Lekana-Douki, Gédéon Prince Manouana, Josiane Honkpehedji, Georgelin Nguema Ondo, Samira Zoa Assoumou, Sam O'neilla Oye Bingono, Sivaramakrishna Rachakonda, Rodrigue Mintsa Ndong, Srinivas Reddy Pallerla, Joël-Fleury Djoba Siawaya, Peter G. Kremsner, Ayola A. Adegnika |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
Lineage (genetic) Population Vaccine Efficacy MinION Infectious and parasitic diseases RC109-216 Genome Article Variant of concern Humans Transmission Gabon education B.1.1.7 Phylogeny Genetics education.field_of_study Central Africa biology Phylogenetic tree Transmission (medicine) SARS-CoV-2 Incidence Pangolin COVID-19 General Medicine biology.organism_classification Vaccine efficacy B.1.1.318 Infectious Diseases Oxford Nanopore Minion Mutation |
| Zdroj: | International Journal of Infectious Diseases, Vol 114, Iss, Pp 151-154 (2022) International Journal of Infectious Diseases |
| ISSN: | 1201-9712 |
| Popis: | Objective Variants of concern (VOCs) associated with relatively high transmissibility appear to be spreading rapidly in Gabon. Therefore, it is imperative to understand the distribution of several variants of concern in the population, which could have implications for transmissibility and vaccine efficacy. Methods Between February and May 2021, SARS-CoV-2 genomes were sequenced using the Oxford nanopore MinION method and the respective genome diversity was elucidated. Phylogenetic analysis was performed and genomes were classified using pangolin lineages. Results The results highlight the increase (46%) of the alpha variant of concern (B.1.1.7) in the Gabonese population over the study period. In addition, an increase (31%) in the B.1.1.318 lineage, which is associated with high transmission and impaired vaccine efficacy (D614G+E484K+Y144del), was detected. Conclusion With the second wave ongoing, our findings highlight the need for surveillance of the SARS-CoV-2 genome in the Republic of Gabon and should provide useful guidance to policy makers in selecting an appropriate vaccine for the population. |
| Databáze: | OpenAIRE |
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