A Biological Index to Screen Multi-Micronutrient Deficiencies Associated with the Risk to Develop Dementia in Older Persons from the Community
| Autor: | Cécile Delcourt, Marjorie Gourru, Catherine Helmer, Sophie Lefèvre-Arbogast, Catherine Féart, Aline M. Thomas, Alexandra Foubert-Samier, Jeanne Neuffer, Cécilia Samieri |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Gerontology Index (economics) Population Risk Factors Fatty Acids Omega-3 Vitamin D and neurology medicine Humans Dementia Nutritional Physiological Phenomena Prospective Studies education Aged Calcifediol education.field_of_study business.industry Proportional hazards model General Neuroscience Malnutrition General Medicine medicine.disease Micronutrient Carotenoids Diet Psychiatry and Mental health Clinical Psychology Cognitive Aging Cohort Female Geriatrics and Gerontology business Biomarkers |
| Zdroj: | Journal of Alzheimer's Disease. 85:331-342 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-215011 |
| Popis: | Background: Low blood status in several nutritional compounds, including long-chain omega-3 fatty acids (LC n-3 PUFA), carotenoids, and vitamin D, have been associated with a higher risk to develop dementia. Nutritional deficiencies may potentiate each other regarding dementia risk; yet the association of multiple nutritional deficiencies with dementia has been little explored. Objective: To develop an index of micronutritional biological status (MNBS) for the screening of multi-micronutritional deficiencies associated with the risk of dementia in a prospective population-based cohort of older persons. Methods: We included participants from the Bordeaux Three-City study, who were free of dementia at baseline, had blood measurements of LC n-3 PUFA, carotenoids, and 25(OH)D, and who were followed for up to 18 years for dementia. We used penalized splines in Cox models to model dose-response relationships of each nutritional component with the risk of dementia and construct a risk index. Results: 629 participants with an average age of 73.1 years were included in the study. Each increase of 1 SD of the MNBS index was associated with a 46%higher risk of dementia (HR = 1.46, 95%CI 1.23; 1.73). Participants with highest index ([mean+1SD; max]) had a 4-fold increased risk of dementia compared with participants with a low index ([min; mean-1SD]) (HR = 4.17, 95%CI 2.30; 7.57). Conclusion: This index of assessment of micronutritional biological status is a practical tool that may help identify populations with inadequate nutritional status, screen eligible individuals for nutritional prevention in primary care, or for supplementation in preventive trials of dementia. |
| Databáze: | OpenAIRE |
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