Mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) as multivalent lectin-binding nanomaterials
| Autor: | Wanda Celentano, Stefania Ordanini, Anna Bernardi, Francesco Cellesi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Glycopolymer
General Physics and Astronomy Nanoparticle ring-opening polymerization (rop) 02 engineering and technology 010402 general chemistry lcsh:Chemical technology 01 natural sciences lcsh:Technology Full Research Paper chemistry.chemical_compound glycopolymer Copolymer Nanotechnology General Materials Science lcsh:TP1-1185 atom transfer radical polymerization (atrp) Electrical and Electronic Engineering lcsh:Science biology poly(ethylene glycol) lcsh:T Ligand binding assay 021001 nanoscience & nanotechnology Combinatorial chemistry lcsh:QC1-999 0104 chemical sciences Nanoscience chemistry Concanavalin A biology.protein lectin lcsh:Q atom transfer radical polymerization (ATRP) poly(ε-caprolactone) ring-opening polymerization (ROP) 0210 nano-technology Ethylene glycol Caprolactone lcsh:Physics Macromolecule |
| Zdroj: | Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 2192-2206 (2019) Beilstein Journal of Nanotechnology |
| ISSN: | 2190-4286 |
| Popis: | A class of linear and four-arm mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) is presented here. The synthesis through ring-opening and atom transfer radical polymerizations provided high control over molecular weight and functionality. A post-polymerization azide–alkyne cycloaddition allowed for the formation of glycopolymers with different mannose valencies (1, 2, 4, and 8). In aqueous media, these macromolecules formed nanoparticles that were able to bind lectins, as investigated by concanavalin A binding assay. The results indicate that carbohydrate–lectin interactions can be tuned by the macromolecular architecture and functionality, hence the importance of these macromolecular properties in the design of targeted anti-pathogenic nanomaterials. |
| Databáze: | OpenAIRE |
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