Novel thermo-responsive micelles prepared from amphiphilic hydroxypropyl methyl cellulose-block-JEFFAMINE copolymers

Autor: Yuandou Wang, Suming Li, Feng Su, Aijing Lu, Sophie Monge, Eddy Petit
Přispěvatelé: Institut Européen des membranes (IEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM), College of chemical engineering Qingdao University of Science and Technology, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Rok vydání: 2019
Předmět:
topology
Chemical Phenomena
Polymers
02 engineering and technology
Biochemistry
Micelle
Hydroxypropyl methyl cellulose
thermo-responsive
Surface-Active Agents
03 medical and health sciences
chemistry.chemical_compound
Hypromellose Derivatives
Dynamic light scattering
Structural Biology
micelle
Amphiphile
Copolymer
[CHIM]Chemical Sciences
JEFFAMINE
Molecular Biology
Micelles
030304 developmental biology
0303 health sciences
Molecular Structure
Spectrum Analysis
technology
industry
and agriculture
self-assembly
General Medicine
021001 nanoscience & nanotechnology
body regions
[CHIM.POLY]Chemical Sciences/Polymers
Chemical engineering
chemistry
Critical micelle concentration
Methyl cellulose
Thermodynamics
Self-assembly
0210 nano-technology
Drug carrier
Hydrophobic and Hydrophilic Interactions
Zdroj: International Journal of Biological Macromolecules
International Journal of Biological Macromolecules, Elsevier, 2019, 135, pp.38-45. ⟨10.1016/j.ijbiomac.2019.05.087⟩
ISSN: 0141-8130
Popis: A series of amphiphilic and thermo-responsive block copolymers were synthesized by reductive amination between the aldehyde endgroup of hydrophilic HPMC and the amine group of monoamine, diamine, or triamine JEFFAMINE as hydrophobic block. The resulting diblock, triblock and three-armed copolymers with different hydrophilic/hydrophobic ratios and block lengths were characterized by NMR, FT-IR, DOSY-NMR and SEC. The cloud point (CP) of copolymers was determined by UV–visible spectrometer. Data show that both the geometrical structure and the molar mass of HPMC affect the CP of HPMC-JEF copolymers. The higher the hydrophilic/hydrophobic ratio, the higher the CP of copolymers which is lower than that of HPMC homopolymers. The self-assembly behavior of the copolymers was investigated from dynamic light scattering, transmission electron microscopy, and critical micelle concentration (CMC) measurements. Spherical nano-micelles are obtained by self-assembly of copolymers in aqueous solution, and the micelle size can be tailored by varying the block length of HPMC and the geometrical structure. Three-armed HPMC-JEF copolymers present lower CMC and smaller micelle size as compared to linear diblock and triblock ones. MTT assay evidenced the cytocompatibility of HPMC-JEF copolymers, indicating that they could be promising as drug carrier in drug delivery systems.
Databáze: OpenAIRE
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