Effects of sex steroids on the proliferation of thymic epithelial cells in a culture model: A role of protein kinase C
| Autor: | Kanji Seiki, Rie Urano, Kou Sakabe, Issei Kawashima, Tsunetoshi Itoh |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class TEC Immunology Thymus Gland Biology Cell Line Immunoenzyme Techniques 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Immunology and Allergy Gonadal Steroid Hormones Receptor Progesterone Protein Kinase C Protein kinase C Estradiol Cell growth Dihydrotestosterone Epithelial Cells DNA Cell Biology Androgen Rats 030104 developmental biology Endocrinology Mechanism of action Cell culture medicine.symptom Cell Division 030215 immunology medicine.drug |
| Zdroj: | Immunology and Cell Biology. 72:193-199 |
| ISSN: | 0818-9641 |
| DOI: | 10.1038/icb.1994.29 |
| Popis: | Using a rat thymic epithelial cell line (TEC; IT-45R1), the present study attempted to elucidate the mechanism of action of sex steroid hormones (SH) on the proliferation of TEC. The findings were as follows: (a) the proliferation of TEC in response to SH was mediated through protein kinase C activity introduced as a result of interaction between SH and plasma-borne inhibitors; (b) the strong inhibitory effect of SH on TEC proliferation might be mediated through the SH receptor pathway because the proliferative response was triggered by progesterone (P) and androgen (A), whereas the inhibitory response was triggered by P, A and oestrogen. These results clearly suggest that the control of TEC proliferation is a 'shut-off' mechanism triggered by high plasma levels of SH. This further refers to the speculation that the development of the normal thymus may be due to a lack of this 'shut-off' mechanism so that development occurs at the adequate plasma SH levels that are often observed before puberty. However, this development is inhibited at the high plasma SH levels after puberty and/or during pregnancy. |
| Databáze: | OpenAIRE |
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