Peripheral blood leukocyte populations and urinary neopterin during chemotherapy in patients with breast cancer
| Autor: | Vladimíra Řezáčová, Dagmar Solichová, Doris Vokurková, Roman Havlik, Lenka Kujovská Krčmová, Jiří Haviger, Pavlína Králíčková, Bohuslav Melichar |
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| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_specialty primary chemotherapy peripheral blood lymphocytes medicine.medical_treatment Urinary system Clinical Biochemistry Biochemistry 03 medical and health sciences chemistry.chemical_compound breast cancer 0302 clinical medicine Breast cancer Internal medicine medicine In patient skin and connective tissue diseases Chemotherapy Crystallography business.industry Neopterin medicine.disease Peripheral blood neopterin chemistry QD901-999 030220 oncology & carcinogenesis Molecular Medicine business 030215 immunology |
| Zdroj: | Pteridines, Vol 27, Iss 3-4, Pp 67-75 (2016) |
| ISSN: | 2195-4720 0933-4807 |
| Popis: | The aim of the present study was to investigate serial changes in urinary neopterin and the populations of peripheral blood lymphocytes in breast cancer patients treated with primary chemotherapy. Thirty patients with breast cancer, including 20 patients undergoing primary chemotherapy treated with the combination of doxorubicin and cyclophosphamide with sequential administration of paclitaxel-based therapy (cohort A), and 10 patients presenting for first-line therapy of metastatic disease and treated with the combination of bevacizumab, taxane and carboplatin (cohort M) were studied. Healthy female blood donors served as control group. Significant differences were observed in baseline relative and absolute counts of peripheral blood lymphocyte subpopulations between both patient cohorts and controls. Significant changes of peripheral blood lymphocyte subpopulations were also observed during the course of chemotherapy. However, no significant changes of urinary neopterin concentrations and no correlation between urinary neopterin and peripheral blood lymphocyte counts were observed. In conclusion, present data demonstrate the presence of significant differences in peripheral blood leukocyte phenotype in breast cancer patients even before the start of primary chemotherapy. Significant changes were observed during the course of chemotherapy. |
| Databáze: | OpenAIRE |
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