Cholinergic Regulatory Lymphocytes Re-Establish Neuromodulation of Innate Immune Responses in Sepsis
| Autor: | Bolin Cai, Edwin A. Deitch, Gergely Vida, Laura Ramos, Luis Ulloa, Geber Peña |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
alpha7 Nicotinic Acetylcholine Receptor Neuroimmunomodulation Immunology Mice Nude Inflammation Punctures Receptors Nicotinic Biology T-Lymphocytes Regulatory Article law.invention Sepsis Mice Random Allocation law medicine Animals Immunology and Allergy IL-2 receptor Cecum Ligation Innate immune system Vagus Nerve medicine.disease Endotoxemia Immunity Innate Mice Mutant Strains Neuromodulation (medicine) Vagus nerve Mice Inbred C57BL Suppressor Cholinergic medicine.symptom |
| Zdroj: | The Journal of Immunology. 187:718-725 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.1100013 |
| Popis: | Many anti-inflammatory strategies that are successful in treating sepsis in healthy animals fail in clinical trials, in part because sepsis normally involves immunocompromised patients, and massive lymphocyte apoptosis prevents immunomodulation. In this article, we report a new set of regulatory lymphocytes that are able to re-establish the cholinergic anti-inflammatory modulation and to provide therapeutic advantages in sepsis. The vagus nerve controls inflammation in healthy, but not in septic, mice. Likewise, vagus nerve and cholinergic agonists fail to control inflammation in splenectomized and nude animals. Unlike typical suppressor CD25+ cells, CD4+CD25− lymphocytes re-establish the anti-inflammatory potential of the vagus nerve and cholinergic agonists in immunocompromised and septic animals. These cholinergic lymphocytes re-establish splenic protection and the potential of cholinergic agonists to rescue immunocompromised animals from established sepsis. The study results revealed these new regulatory lymphocytes as, to our knowledge, the first known physiological target for neuromodulation of the innate immune responses and a potential therapeutic target for sepsis. |
| Databáze: | OpenAIRE |
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