What If I Don’t Have Blood? Hextend is Superior to 3% Saline in an Experimental Model of Far Forward Resuscitation After Hemorrhage
| Autor: | Peter L. Jernigan, Timothy A. Pritts, Daniel Cox, Warren C. Dorlac, Judy Heyl, Richard S. Hoehn |
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| Rok vydání: | 2016 |
| Předmět: |
Mean arterial pressure
Resuscitation Blood transfusion Swine medicine.medical_treatment Hemodynamics Blood Pressure Hemorrhage 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Hydroxyethyl Starch Derivatives 03 medical and health sciences 0302 clinical medicine medicine Animals Arterial Pressure Blood Transfusion Saline Saline Solution Hypertonic Interleukin-6 business.industry 030208 emergency & critical care medicine Metabolic acidosis medicine.disease Hypertonic saline Disease Models Animal Treatment Outcome Blood pressure Anesthesia Splenectomy Emergency Medicine Fluid Therapy Female business |
| Zdroj: | Shock. 46:148-153 |
| ISSN: | 1073-2322 |
| Popis: | INTRODUCTION Hypertonic crystalloid solutions, colloids, and fresh whole blood (FWB) have all been proposed for prehospital resuscitation after hemorrhage. However, there are no direct comparisons of the efficacy of these different fluids. We compared Hextend, 3% hypertonic saline (HS), and FWB in a porcine model of hemorrhagic shock. MATERIALS AND METHODS Female swine (n = 5/group) underwent splenectomy and pressure-controlled hemorrhage followed by resuscitation with Hextend, 3% HS, or FWB. They were maintained at a target mean arterial pressure (MAP) for 4 h, holding or infusing fluid as necessary. Sham animals for comparison underwent splenectomy alone. RESULTS The mean volume required to maintain target MAP was significantly higher for 3% HS (1,016 ± 386 mL) than for Hextend (346 ± 299 mL, P |
| Databáze: | OpenAIRE |
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