Progressive Retinitis-Encephalitis Due to Ganciclovir-Resistant Cytomegalovirus Associated with Aplastic Anemia
| Autor: | Takashi Sasaki, Akihiko Okayama, Nobuhisa Nao-i, Yoichi Minamishima, Koichi Murai, Masashi Koono, Hitoshi Matsuoka, Hisamitsu Uno, Atsushi Sawada, Nobuyoshi Tachibana, Yoshihisa Matsuura, Hirohito Tsubouchi, Yoshito Eizuru, Hiroaki Kataoka |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Ganciclovir medicine.medical_specialty Anemia viruses Congenital cytomegalovirus infection Cytomegalovirus Retinitis Antiviral Agents Gastroenterology Betaherpesvirinae Internal medicine Internal Medicine Humans Medicine Encephalitis Viral Aplastic anemia biology business.industry Anemia Aplastic virus diseases Drug Resistance Microbial General Medicine Retinite biology.organism_classification medicine.disease Cytomegalovirus Retinitis Immunology Female business Encephalitis medicine.drug |
| Zdroj: | Internal Medicine. 36:375-379 |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | A 29-year-old woman with aplastic anemia who complained of visual disturbances and pain in the right eyeball was diagnosed as having cytomegalovirus (CMV) retinitis based upon the characteristic retinal changes and isolation of CMV. She received treatment with ganciclovir (GCV), and the retinitis initially responded for several months. However, the patient was found to have CMV lesions in the left eye followed by neurological symptoms. The CMV isolated just before her death was approximately 20 times more resistant to GCV than that isolated previously, suggesting that the GCV-resistant CMV had developed during the long-term treatment with GCV. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|