Carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in Indonesian children: A cross-sectional study
| Autor: | Rodman Tarigan, Chrysanti Murad, Finny Fitry Yani, Sang Ayu Kompiyang Indriyani, Eddy Fadlyana, E. Kim Mulholland, Casey L Pell, Jason Hinds, Catherine Satzke, Nurhandini Eka Dewi, Sunaryati Sudigdoadi, Emma Watts, Cissy B. Kartasasmita, Eileen M. Dunne, Kusnandi Rusmil |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Latex Microarrays Staphylococcus Child Health Services lcsh:Medicine medicine.disease_cause Pathology and Laboratory Medicine Pediatrics Polymerase Chain Reaction Haemophilus influenzae Moraxella catarrhalis Geographical Locations Mycoplasma Nasopharynx Medicine and Health Sciences Odds Ratio Mycoplasma Pneumoniae Public and Occupational Health Staphylococcus Aureus lcsh:Science Haemophilus Influenzae Oligonucleotide Array Sequence Analysis Multidisciplinary biology Geography Child Health Pneumococcus Staphylococcal Infections Bacterial Pathogens Bacterial Typing Techniques Pneumococcal infections Bioassays and Physiological Analysis Streptococcus pneumoniae Medical Microbiology Child Preschool Carrier State Female Quellung reaction Pathogens Research Article Asia Haemophilus Infections Moraxellaceae Infections 030106 microbiology Oceania Haemophilus Mollicutes Staphylococcal infections Research and Analysis Methods Microbiology Pneumococcal Infections 03 medical and health sciences medicine Humans Serotyping Microbial Pathogens Bacteria lcsh:R Organisms Biology and Life Sciences Streptococcus Infant biology.organism_classification medicine.disease Carriage Cross-Sectional Studies Pneumococcal vaccine Indonesia People and Places lcsh:Q |
| Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 4, p e0195098 (2018) |
| ISSN: | 1932-6203 |
| Popis: | Streptococcus pneumoniae is an important cause of infection and commonly colonizes the nasopharynx of young children, along with other potentially pathogenic bacteria. The objectives of this study were to estimate the carriage prevalence of S. pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in young children in Indonesia, and to examine interactions between these bacterial species. 302 healthy children aged 12-24 months were enrolled in community health centers in the Bandung, Central Lombok, and Padang regions. Nasopharyngeal swabs were collected and stored according to World Health Organization recommendations, and bacterial species detected by qPCR. Pneumococcal serotyping was conducted by microarray and latex agglutination/Quellung. Overall carriage prevalence was 49.5% for S. pneumoniae, 27.5% for H. influenzae, 42.7% for M. catarrhalis, and 7.3% for S. aureus. Prevalence of M. catarrhalis and S. pneumoniae, as well as pneumococcal serotype distribution, varied by region. Positive associations were observed for S. pneumoniae and M. catarrhalis (OR 3.07 [95%CI 1.91-4.94]), and H. influenzae and M. catarrhalis (OR 2.34 [95%CI 1.40-3.91]), and a negative association was found between M. catarrhalis and S. aureus (OR 0.06 [95%CI 0.01-0.43]). Densities of S. pneumoniae, H. influenzae, and M. catarrhalis were positively correlated when two of these species were present. Prior to pneumococcal vaccine introduction, pneumococcal carriage prevalence and serotype distribution varies among children living in different regions of Indonesia. Positive associations in both carriage and density identified among S. pneumoniae, H. influenzae, and M. catarrhalis suggest a synergistic relationship among these species with potential clinical implications. |
| Databáze: | OpenAIRE |
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