Anti-tumor properties of orally administered glucosamine and N-acetyl-d-glucosamine oligomers in a mouse model
| Autor: | Saburo Minami, Tomohiro Imagawa, Norihiko Itoh, Yoshiharu Okamoto, Masatoshi Kiyose, Kazuo Azuma, Tomohiro Osaki, Seiji Kurozumi, Kimihiko Sato, Sachie Masuda, Takeshi Tsuka |
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| Rok vydání: | 2014 |
| Předmět: |
Polymers and Plastics
Colon Administration Oral Antineoplastic Agents Apoptosis Stimulation Pharmacology Oligomer Acetylglucosamine Interferon-gamma Mice chemistry.chemical_compound Immune system Glucosamine Oral administration Materials Chemistry Animals Mice Inbred BALB C Innate immune system Organic Chemistry Immunity Innate Disease Models Animal chemistry Biochemistry Colonic Neoplasms Knockout mouse Cytokines Female |
| Zdroj: | Carbohydrate Polymers. 111:783-787 |
| ISSN: | 0144-8617 |
| Popis: | The current study evaluated the anti-tumor activities of N-acetyl-d-glucosamine oligomer (NACOS) and glucosamine oligomer (COS) after their oral administration in a tumor (colon 26)-bearing mouse model. Compared to the control group, NACOS and COS groups showed significantly suppressed tumor growth, and apparent, marked apoptosis in tumor tissues. Furthermore, serum interleukin-12p70 and interferon-γ levels significantly increased in the NACOS and COS groups compared to the corresponding levels in the control group. Collectively, the results indicate the oral administration of NACOS and COS could enhance innate immunity. Results of experiments in Myd-88 knockout mice revealed that the apparent effects were related to both Myd-88-dependent and Myd-88-independent pathways. The data indicated that oral administration of NACOS and COS produced anti-tumor effects through the induction of apoptosis and stimulation of the immune system, which suggests that NACOS and COS are candidate anti-tumor functional foods. |
| Databáze: | OpenAIRE |
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