Serotonergic modulation of nicotine-induced kinetic tremor in mice
| Autor: | Misaki Onishi, Yukihiro Ohno, Higor A. Iha, Nami Matsubara, Naofumi Kunisawa, Saki Shimizu, Yuji Nomura |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Agonist Male Nicotine medicine.drug_class Ritanserin Pharmacology Piperazines 03 medical and health sciences Mice 0302 clinical medicine 5-HT2 receptors Tremor medicine Animals Humans heterocyclic compounds Kinetic tremor 5-HT receptor 8-Hydroxy-2-(di-n-propylamino)tetralin Chemistry musculoskeletal neural and ocular physiology lcsh:RM1-950 Amphetamines Antagonist Fenclonine Ondansetron Serotonin Receptor Agonists 030104 developmental biology Nicotinic agonist lcsh:Therapeutics. Pharmacology nervous system Receptors Serotonin Receptor Serotonin 5-HT1A Molecular Medicine 5-HT1A receptors α7 nACh receptors Serotonin Antagonists 030217 neurology & neurosurgery Acetylcholine medicine.drug |
| Zdroj: | Journal of Pharmacological Sciences, Vol 134, Iss 2, Pp 131-138 (2017) |
| ISSN: | 1347-8648 |
| Popis: | We previously demonstrated that nicotine elicited kinetic tremor by elevating the neural activity of the inferior olive via α7 nicotinic acetylcholine (nACh) receptors. Since α7 nACh receptors reportedly facilitate synaptic monoamine release, we explored the role of 5-HT receptors in induction and/or modulation of nicotine tremor. Treatment of mice with nicotine induced kinetic tremor that normally appeared during movement. The 5-HT1A agonist, 8-hydroxydipropylaminotetraline (8-OH-DPAT), significantly enhanced nicotine-induced tremor and the action of 8-OH-DPAT was antagonized by WAY-100135 (5-HT1A antagonist). In addition, the cerebral 5-HT depletion by repeated treatment with p-chlorophenylalanine did not reduce, but rather potentiated the facilitatory effects of 8-OH-DPAT. In contrast, the 5-HT2 agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), significantly attenuated nicotine tremor, which was antagonized by ritanserin (5-HT2 antagonist). The 5-HT3 agonist SR-57227 did not affect nicotine-induced tremor. Furthermore, when testing the direct actions of 5-HT antagonists, nicotine tremor was inhibited by WAY-100135, but was unaffected by ritanserin, ondansetron (5-HT3 antagonist) or SB-258585 (5-HT6 antagonist). These results suggest that postsynaptic 5-HT1A receptors are involved in induction of nicotine tremor mediated by α7 nACh receptors. In addition, 5-HT2 receptors have an inhibitory modulatory role in induction of nicotine tremor. |
| Databáze: | OpenAIRE |
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