Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors
| Autor: | Giuseppe Donato, Alfredo Fusco, Andrea Amorosi, Lorenza Maltese, G Iofrida, Francesco Conforti, Dario Palmieri, Francesco Signorelli, Volpentesta G, Luigi Tucci, Angelo Lavano, Pierlorenzo Pallante, M G Pierantoni, Maria Teresa Berlingieri |
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| Přispěvatelé: | Donato, G., Iofrida, G., Lavano, A., Volpentesta, G., Signorelli, F., Pallante, P., Berlingieri, M. T., Pierantoni, GIOVANNA MARIA, Palmieri, Dario, Conforti, F., Maltese, L., Tucci, L., Amorosi, A., Fusco, Alfredo |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.medical_treatment Gene Expression Astrocytoma Biology Pathology and Forensic Medicine Gene expression Biomarkers Tumor medicine Humans astrocytic tumor Gene Chemotherapy Brain Neoplasms General Medicine medicine.disease UbcH10 Neurology Gliosis Expression (architecture) Proteasome Ubiquitin-Conjugating Enzymes immunohistochemistry Immunohistochemistry Neurology (clinical) medicine.symptom |
| Zdroj: | Scopus-Elsevier Clinical neuropathology 27 (2008): 219–223. info:cnr-pdr/source/autori:Donato G, Iofrida G, Lavano A, Volpentesta G, Signorelli F, Pallante PL, Berlingieri MT, Pierantoni MG, Palmieri D, Conforti F, Maltese L, Tucci L, Amorosi A, Fusco A./titolo:Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors./doi:/rivista:Clinical neuropathology/anno:2008/pagina_da:219/pagina_a:223/intervallo_pagine:219–223/volume:27 |
| Popis: | Previous studies suggest the expression of UbcH10 gene, that codes for a protein belonging to the ubiquitin-conjugating enzyme family, as a valid indicator of the proliferative and aggressive status of tumors of different origin. Therefore, to look for possible tools to be used as diagnostic markers in astrocytic neoplasias, we investigated UbcH10 expression in normal brain, gliosis and low-grade and high-grade astrocytic tumors by immunohistochemistry. UbcH10 expression was observed in low-grade astrocytoma and in glioblastoma. Our data indicate a clear correlation between UbcH10 expression and the histological grade of the astrocytic tumors. Moreover, the analysis of UbcH10 expression allows the differentiation between gliotic and malignant tissues. Finally, since proteasome inhibitors have recently been considered as possible drugs in the chemotherapy of various tumors, our results would suggest new perspectives for the treatment of brain malignancies based on the suppression of the UbcH10 function. |
| Databáze: | OpenAIRE |
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