Pentoxifylline Does Not Prevent Haemodialysis Induced Neutropaenia or Hypoxaemia
| Autor: | Brian Rayner, G. Thebus, M.D Pascoe |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Neutropenia Partial Pressure medicine.medical_treatment Pentoxifylline Hypoxemia Leukocyte Count Renal Dialysis Oral administration Humans Medicine Hypoxia Dialysis Chemotherapy business.industry Cuprophane medicine.disease Surgery Oxygen Anesthesia Kidney Failure Chronic Hemodialysis medicine.symptom business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 2235-3186 1660-8151 |
| DOI: | 10.1159/000186780 |
| Popis: | The aim of the study was to determine if oral pentoxifylline prevented dialysis induced hypoxaemia and neutropaenia. Fifteen stable chronic haemodialysis patients were routinely dialysed using either a cuprophane or cellulose acetate membrane. Bloods for white blood count (WCC) and pO2 were taken at time 0, 20, 80, 140 and 200 min. The procedure was repeated in the same patients 2 h after the ingestion of 400 mg of pentoxifylline. There was a highly significant drop in WCC at time 20 min and pO2 over the dialysis period, which was not prevented by pentoxifylline. Pentoxifylline levels taken at time 0 in 11 patients were in the therapeutic range and it is concluded that pentoxifylline does not prevent dialysis induced neutropaenia or hypoxaemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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